What DSIP is
DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide originally isolated in the 1970s from the cerebral venous blood of sleep-induced rabbits, in a research programme investigating putative sleep-active endogenous factors. It has since been studied across neuroscience, endocrinology and stress-response research.
Molecular information
- Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE)
- Number of residues: 9
- Approximate monoisotopic mass: ~849 Da (as the free acid)
- Physical form: Typically supplied as a white lyophilised powder
Areas of published research
Preclinical research on DSIP has examined its influence on sleep architecture in animal models, its interaction with the hypothalamic-pituitary axis and its effects in stress-response models. The peptide is short and hydrophilic; reversed-phase HPLC methods should provide adequate retention.
Analytical considerations
Standard research-peptide analytical checks apply: identity confirmation by mass spectrometry (see LC-MS peptide testing explained), purity assessment by reversed-phase HPLC at 214 nm (see what is HPLC peptide testing), and batch-specific documentation (see how to read a peptide COA). Refer to the Peptovia Research Certificate of Analysis page for live examples of the analytical format used for batches supplied.
Further reading
Peer-reviewed literature on DSIP is accessible via PubMed and specialist journals. Readers are encouraged to evaluate primary sources directly rather than relying on secondary summaries.
Research Use Only. This profile is an educational overview of DSIP as a research peptide. It does not describe or recommend human, veterinary or clinical use. Peptovia Research supplies DSIP strictly for in-vitro laboratory research. No dosing, administration or therapeutic guidance is provided or implied.