What MOTS-c is
MOTS-c (mitochondrial-derived peptide encoded in the 12S rRNA) is a naturally occurring 16-residue peptide encoded within the mitochondrial genome. It was discovered in the 2010s and has since become an active area of mitochondrial-biology research.
Molecular information
- Sequence: MRWQEMGYIFYPRKLR
- Number of residues: 16
- Approximate monoisotopic mass: ~2174 Da (as the free acid)
- Physical form: Typically supplied as a white lyophilised powder
Areas of published research
Preclinical research has examined MOTS-c in the context of insulin sensitivity, AMPK signalling, mitochondrial function and metabolic-stress models. Because MOTS-c contains methionine, tryptophan and tyrosine residues, analytical handling should consider oxidation as a possible synthesis-related side product.
Analytical considerations
Standard research-peptide analytical checks apply: identity confirmation by mass spectrometry (see LC-MS peptide testing explained), purity assessment by reversed-phase HPLC at 214 nm (see what is HPLC peptide testing), and batch-specific documentation (see how to read a peptide COA). Refer to the Peptovia Research Certificate of Analysis page for live examples of the analytical format used for batches supplied.
Further reading
Peer-reviewed literature on MOTS-c is accessible via PubMed and specialist journals. Readers are encouraged to evaluate primary sources directly rather than relying on secondary summaries.
Research Use Only. This profile is an educational overview of MOTS-c as a research peptide. It does not describe or recommend human, veterinary or clinical use. Peptovia Research supplies MOTS-c strictly for in-vitro laboratory research. No dosing, administration or therapeutic guidance is provided or implied.