What PT-141 is
PT-141 (also called Bremelanotide) is a synthetic cyclic heptapeptide, closely related to Melanotan-2 in structure, developed as a research probe for the melanocortin-4 receptor (MC4R) and related melanocortin-receptor subtypes.
Molecular information
- Sequence: Cyclic [Nle-Asp-His-D-Phe-Arg-Trp-Lys]-OH (structural analogue of MT-2 without the C-terminal amide)
- Number of residues: 7 (cyclic)
- Approximate monoisotopic mass: ~1025 Da (as the free acid)
- Physical form: Typically supplied as a white lyophilised powder
Areas of published research
Preclinical and clinical research has examined PT-141 in the context of melanocortin-receptor signalling. Its structural similarity to Melanotan-2 means that analytical differentiation between the two peptides depends on precise mass measurement — high-resolution LC-MS is recommended.
Analytical considerations
Standard research-peptide analytical checks apply: identity confirmation by mass spectrometry (see LC-MS peptide testing explained), purity assessment by reversed-phase HPLC at 214 nm (see what is HPLC peptide testing), and batch-specific documentation (see how to read a peptide COA). Refer to the Peptovia Research Certificate of Analysis page for live examples of the analytical format used for batches supplied.
Further reading
Peer-reviewed literature on PT-141 is accessible via PubMed and specialist journals. Readers are encouraged to evaluate primary sources directly rather than relying on secondary summaries.
Research Use Only. This profile is an educational overview of PT-141 as a research peptide. It does not describe or recommend human, veterinary or clinical use. Peptovia Research supplies PT-141 strictly for in-vitro laboratory research. No dosing, administration or therapeutic guidance is provided or implied.