What SS-31 is
SS-31 (also called Elamipretide) is a synthetic tetrapeptide developed as a mitochondrial-targeted research compound. Its cationic character and specific amino-acid composition give it affinity for the inner-mitochondrial-membrane phospholipid cardiolipin.
Molecular information
- Sequence: D-Arg-2',6'-dimethyl-Tyr-Lys-Phe-NH₂
- Number of residues: 4
- Approximate monoisotopic mass: ~640 Da (as the free acid)
- Physical form: Typically supplied as a white lyophilised powder
Areas of published research
SS-31 has been extensively studied in preclinical models of mitochondrial dysfunction, ischemia-reperfusion, cardiac disease models and age-related mitochondrial decline. The presence of the modified tyrosine residue (2',6'-dimethyl-Tyr) and D-arginine is analytically significant.
Analytical considerations
Standard research-peptide analytical checks apply: identity confirmation by mass spectrometry (see LC-MS peptide testing explained), purity assessment by reversed-phase HPLC at 214 nm (see what is HPLC peptide testing), and batch-specific documentation (see how to read a peptide COA). Refer to the Peptovia Research Certificate of Analysis page for live examples of the analytical format used for batches supplied.
Further reading
Peer-reviewed literature on SS-31 is accessible via PubMed and specialist journals. Readers are encouraged to evaluate primary sources directly rather than relying on secondary summaries.
Research Use Only. This profile is an educational overview of SS-31 as a research peptide. It does not describe or recommend human, veterinary or clinical use. Peptovia Research supplies SS-31 strictly for in-vitro laboratory research. No dosing, administration or therapeutic guidance is provided or implied.