What TB-500 is
TB-500 is a synthetic peptide corresponding to a bioactive fragment of Thymosin beta-4 (Tβ4), a naturally occurring 43-residue G-actin-sequestering peptide with a well-characterised role in cytoskeletal biology and tissue repair. The commercial 'TB-500' preparation is a short, chemically stable analogue of the Tβ4 sequence.
Molecular information
- Sequence origin: Fragment/analogue of Thymosin beta-4
- Number of residues: Typically around 7 (specific sequence varies with the supplier's preparation)
- Approximate monoisotopic mass: Consult the batch COA — varies by preparation
- Physical form: Typically supplied as a white lyophilised powder
Areas of published research
Preclinical research on Thymosin beta-4 and its fragments has examined tissue-repair, vascular and inflammation-resolution biology. Because 'TB-500' preparations differ in exact composition between suppliers, batch-specific identity and purity documentation is particularly important — see why batch-specific peptide COAs matter.
Analytical considerations
Standard research-peptide analytical checks apply: identity confirmation by mass spectrometry (see LC-MS peptide testing explained), purity assessment by reversed-phase HPLC at 214 nm (see what is HPLC peptide testing), and batch-specific documentation (see how to read a peptide COA). Refer to the Peptovia Research Certificate of Analysis page for live examples of the analytical format used for batches supplied.
Further reading
Peer-reviewed literature on TB-500 is accessible via PubMed and specialist journals. Readers are encouraged to evaluate primary sources directly rather than relying on secondary summaries.
Research Use Only. This profile is an educational overview of TB-500 as a research peptide. It does not describe or recommend human, veterinary or clinical use. Peptovia Research supplies TB-500 strictly for in-vitro laboratory research. No dosing, administration or therapeutic guidance is provided or implied.